Gene Expression Mural
نویسندگان
چکیده
The Gene Expression Mural is a tool designed for managing the vast amount of information produced by the rapidly growing field of Bioinformatics. The advantages of this tool are that it not only provides an overview of many experiments for an entire genome, but also promotes discovery with its zooming and navigation capabilities. A “tier array” data structure and an averaging algorithm were implemented to facilitate efficient interaction with enormous amounts of data from experiment databases.
منابع مشابه
NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1.
Endothelial cells and mural cells (smooth muscle cells, pericytes, or fibroblasts) are known to communicate with one another. Their interactions not only serve to support fully functional blood vessels but also can regulate vessel assembly and differentiation or maturation. In an effort to better understand the molecular components of this heterotypic interaction, we used a 3D model of angiogen...
متن کاملEndothelial cells downregulate apolipoprotein D expression in mural cells through paracrine secretion and Notch signaling.
Endothelial and mural cell interactions are vitally important for proper formation and function of blood vessels. These two cell types communicate to regulate multiple aspects of vessel function. In studying genes regulated by this interaction, we identified apolipoprotein D (APOD) as one gene that is downregulated in mural cells by coculture with endothelial cells. APOD is a secreted glycoprot...
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متن کاملNOTCH3 regulates stem-to-mural cell differentiation in infantile hemangioma.
Infantile hemangioma (IH) is a vascular tumor that begins with rapid vascular proliferation shortly after birth, followed by vascular involution in early childhood. We have found that NOTCH3, a critical regulator of mural cell differentiation and maturation, is expressed in hemangioma stem cells (HemSCs), suggesting that NOTCH3 may function in HemSC-to-mural cell differentiation and pathologica...
متن کاملAnalysis of the brain mural cell transcriptome
Pericytes, the mural cells of blood microvessels, regulate microvascular development and function and have been implicated in many brain diseases. However, due to a paucity of defining markers, pericyte identification and functional characterization remain ambiguous and data interpretation problematic. In mice carrying two transgenic reporters, Pdgfrb-eGFP and NG2-DsRed, we found that double-po...
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تاریخ انتشار 2001